| Date | Comp | Home | Score | Away | Scorers |
| 13.08..21 | EPL | Brentford | 2-0 | Arsenal | |
| 22.08.21 | EPL | Arsenal | 0-2 | Chelsea | |
| 25.08.21 | EFLC | West Brom | 0-6 | Arsenal | Aubameyang 17', 45', 62', Pépé 46', Saka 60', Lacazette 69' |
| 28.08.21 | EPL | Man City | 5-0 | Arsenal | |
| 11.09.21 | EPL | Arsenal | 1-0 | Norwich | Aubameyang 66' (Pépé) |
| 18.09.21 | EPL | Burnley | 0-1 | Arsenal | Ødegaard 30' |
| 22.09.21 | EFLC | Arsenal | 3-0 | AFC Wimbledon | Lacazette 11', Smith-Rowe 77' (Lacazette) Nketiah 80' (Soares) |
| 26.09.21 | EPL | Tottenham | 1-3 | Arsenal | Smith-Rowe 12' (Saka), Aubameyang 27' (Smith Rowe), Saka 34' |
| 02.10.21 | EPL | Brighton | 0-0 | Arsenal | |
| 18.10.21 | EPL | Arsenal | 2-2 | Crystal Palace | Aubameyang 8', Lacazette 94' |
| 22.10.21 | EPL | Arsenal | 3-1 | Aston Villa | Partey 30' (Smith-Rowe), Aubameyang 45+', Smith-Rowe 56' (Aubameyang) |
| 26.10.21 | EFLC | Arsenal | 2-0 | Leeds | |
| 30.10.21 | EPL | Leicester | 0-2 | Arsenal | Gabriel 6' (Saka), Smith-Rowe 18' |
